apalutamide will lessen the extent or impact of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine that happen to be CYP3A4 substrates can result in decrease publicity to those medicines.armodafinil will reduce the extent or… Read More